Giampaolo Trivellin.

Lysy, M.D., Ph.D., Emanuele Ferrante, M.D., Ph.D., Natalia Strebkova, M.D., Ph.D., Nadia Mazerkina, M.D., Ph.D., Maria Chiara Zatelli, M.D., Ph.D., Maya Lodish, M.D., Anelia Horvath, Ph.D., Rodrigo Bertollo de Alexandre, Ph.D., Allison D. Manning, M.Sc., Isaac Levy, M.D., Margaret F. Keil, Ph.D., P.N.P., Maria de la Luz Sierra, M.S., Leonor Palmeira, Ph.D., Wouter Coppieters, Ph.D., Michel Georges, D.V.M., Ph.D., Luciana A. Naves, M.D., Ph.D., Mauricette Jamar, M.D., Vincent Bours, M.D., Ph.D., T. John Wu, Ph.D., Catherine S. Choong, M.D., M.B., B.S., Jerome Bertherat, M.D., Ph.D., Philippe Chanson, M.D., Ph.D.D., Ph.D., William E.We demonstrated that the calcineurin pathway is activated particularly in lung endothelium prior to the recognition of tumor cells that preferentially and spontaneously metastasize to the lung from our experimental style of flank tumors in mice, says Ryeom. Also, increased VEGF levels in the lung particularly, rather than other organ microenvironments, trigger a threshold quantity of calcineurin signaling that activates the Ang2 gene in lung endothelial cells.