To find all of them, we’ll need to study millions of patients. Is definitely this unrealistic? I don’t think so.. 32 genetic variations could are likely involved in osteoporosis risk By Dr Ananya Mandal, MD A team of worldwide researchers have found 32 new genetic regions associated with fractures and osteoporosis. In the April 15 online edition of Nature Genetics Based on the new study published, changes in these areas can offer protection from, or better risk for, bone-weakening disease. John Ioannidis, chief of the Stanford Prevention Study Center, stated in a university information release.Te Meerman, Ph.D., Annemieke J.M.H. Verkerk, Ph.D. Uitterlinden, Ph.D., Alessandra Maugeri, Ph.D., Erik A. Sistermans, Ph.D., Quinten Waisfisz, Ph.D., Hanne Meijers-Heijboer, M.D., Ph.D., Brunhilde Wirth, Ph.D., Marleen E.H. Simon, M.D., and Gerard Pals, Ph.D.: Brief Statement: PLS3 Mutations in X-Connected Osteoporosis with Fractures Osteoporosis is a prevalent disorder seen as a low bone mass and microarchitectural deterioration of bone cells, which results in bone fragility and fractures.1 It is diagnosed clinically and often confirmed by calculating bone mineral density .1,2 An understanding of the sources of osteoporosis is very important to its prevention, diagnosis, and treatment. The investigation of uncommon mendelian disorders with decreased BMD as an integral diagnostic feature constitutes a strategy for determining genetic determinants of osteoporosis.