Baseline characteristics before the initial phase didn’t differ significantly between the two study groups, aside from the serum potassium level . The mean age was 65 years ; 60 percent of the sufferers were males, and 86 percent had been white. A total of 561 patients had an eGFR of less than 60 ml each and every minute per 1.73 m2 , 502 sufferers were receiving RAAS inhibitors, 451 had diabetes, and 300 had a brief history of heart failure. There were no significant between-group differences with respect to changes in concomitant therapies, including RAAS inhibitors, diuretics, and antidiabetic drugs. Efficacy Initial Phase ZS-9 was associated with a significant reduction in the serum potassium level from baseline to 48 hours among patients receiving 2.5 g, those receiving 5 g, and the ones receiving 10 g of the drug .Specificity to pain at the design level is consistent with findings that the anterior cingulate cortex and other association regions contain nociceptive-specific neurons as well as neurons with various other properties25 and that machine learning can determine fMRI patterns with specific functional properties.26 The neurologic signature is predominantly bilateral but shows evidence of contralateral specificity in the secondary and primary somatosensory cortexes, an observation that’s in keeping with previous work.15,27 These results build on previous research16,28-31 by showing a signature that has more than 90 percent sensitivity and specificity for discomfort at the level of the average person person and that’s consistently accurate across studies and scanners.