Erkki Savilahti.

Details of the adverse events which were reported are given, according to study group, in Table 4 in the Supplementary Appendix. Discussion Our study showed that among children with an HLA genotype conferring increased risk for type 1 diabetes and a first-level relative with type 1 diabetes, weaning to a highly hydrolyzed formula during infancy was associated with fewer indications of beta-cell autoimmunity up to a decade old. Our study was not powered for any definitive bottom line regarding progression to overt type 1 diabetes, but a larger TRIGR study today ongoing in 15 countries on three continents is designed with adequate power to address that issue.