Tsao, MD, a radiation oncologist at the Odette Malignancy Centre in Toronto, Ontario, Canada, said. ‘However, the ultimate decision in a patient’s care should be made by your physician taking into consideration the medical history of each individual patient.’.. ASTRO creates guideline on radiotherapeutic, surgical management for brain metastases The American Society for Radiation Oncology is rolling out a guideline on the radiotherapeutic and surgical management for newly diagnosed brain metastases. It has been published in Useful Radiation Oncology , ASTRO’s official clinical practice journal. ‘This guideline was developed by a global multidisciplinary task force billed with systematically reviewing and synthesizing level one and additional high-quality data right into a distilled function product,’ Eric L.Two quality 1 chorioretinopathy events had been reported in the combination-therapy group and one in the vemurafenib group. In the vemurafenib group, quality 2 retinal-vein occlusion that was reported in 1 patient was considered to be related to the study drug; simply no retinal-vein occlusion was reported in the combination-therapy group. Discussion In our study, patients with previously untreated metastatic melanoma with BRAF mutations who received combination therapy with dabrafenib and trametinib, in comparison with vemurafenib monotherapy, had a relative reduction of 31 percent in the chance of death.